Hydrochloric Acid → 2-Aminothiazole-4-carboxylic acid

HRID 244658노트

반응식

HRID 244658 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.Cl>O1CCOCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 73216Ethyl 2-aminothiazole-4-carboxylate

생성물 1

HCID 15018822-Aminothiazole-4-carboxylic acid수율 119.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of ethyl 2-amino-1,3-thiazole-4-carboxylate (150 mg) (for example available, from Maybridge Chemical Company) in 1,4-dioxane (3 ml) was added 2M hydrochloric acid (2 ml) and the mixture heated at reflux under nitrogen for 70 h. The mixture was cooled to room temperature and the solvent removed in vacuo. Toluene (15 ml) was added and the solvent removed in vacuo to give a solid that was dried in an vacuum oven overnight to give the title compound (150 mg) as a brown solid.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux under nitrogen for 70 h
  3. customthe solvent removed in vacuo
  4. additionToluene (15 ml) was added
  5. customthe solvent removed in vacuo
  6. customto give a solid
  7. customthat was dried in an vacuum oven overnight

출처 및 근거

ORD 기록
ord-bb195289752f4faaa9ff5bf8e074e332
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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