Hydrochloric Acid → 1-ethyl-4-fluoro-1H-pyrazole-5-carboxylic acid
반응식
[CH2:1]([N:3]1[C:7]([C:8]([O:10]CC)=[O:9])=[C:6]([F:13])[CH:5]=[N:4]1)[CH3:2].Cl>O1CCOCC1>[CH2:1]([N:3]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:13])[CH:5]=[N:4]1)[CH3:2]참가 물질
4
실험 절차
To a solution of ethyl 1-ethyl-4-fluoro-1H-pyrazole-5-carboxylate (67 mg) in 1,4-dioxane (3 ml) was added 2M hydrochloric acid (2 ml) was added and the mixture was heated at reflux under nitrogen for 120 h. The mixture was cooled to room temperature and the solvent was removed in vacuo. Toluene (15 ml) was added and the solvent was removed in vacuo to give a solid that was dried in a vacuum oven overnight to give the title compound (26 mg) as a brown solid.
후처리
- additionwas added
- temperaturethe mixture was heated
- temperatureat reflux under nitrogen for 120 h
- customthe solvent was removed in vacuo
- additionToluene (15 ml) was added
- customthe solvent was removed in vacuo
- customto give a solid
- customthat was dried in a vacuum oven overnight
출처 및 근거
- ORD 기록
- ord-11e4c56967834f96826b35e474adafa2
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08658635B2
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