Sodium Hydroxide → HCID 58356330, 화합물

HRID 244665노트

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HRID 244665 반응식
[CH3:1][CH:2]([N:4]1[N:8]=[C:7]([C:9]([O:11]CC)=[O:10])[CH:6]=[N:5]1)[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([N:4]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[N:5]1)[CH3:1]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58356328HCID 58356328, 화합물

생성물 1

HCID 58356330HCID 58356330, 화합물수율 80.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of ethyl 2-(1-methylethyl)-2H-1,2,3-triazole-4-carboxylate (670 mg) in methanol (6 ml) was added sodium hydroxide (4 ml) and the mixture was stirred at room temperature for 4 h. The methanol was removed in vacuo and water (10 ml) was added and the mixture neutralised (pH 5-6) by the addition of 2M hydrochloric acid. The aqueous layer was extracted with DCM, separated by hydrophobic frit and the organic layer evaporated in vacuo to give the title compound (455 mg) as a white solid.

후처리

  1. customThe methanol was removed in vacuo and water (10 ml)
  2. additionwas added
  3. additionthe mixture neutralised (pH 5-6) by the addition of 2M hydrochloric acid
  4. extractionThe aqueous layer was extracted with DCM
  5. customseparated by hydrophobic frit
  6. customthe organic layer evaporated in vacuo

출처 및 근거

ORD 기록
ord-f3b5fbbcde3d4f048cad099827632a54
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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