Sodium Hydroxide → 5-(1-Methylethyl)-4-thiazolecarboxylic acid
반응식
[CH3:1][CH:2]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]C)=[O:10])[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([OH:11])=[O:10])[CH3:1]참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
To a solution of methyl 5-(1-methylethyl)-1,3-thiazole-4-carboxylate (1.9 g) in methanol (20 ml) was added 2M sodium hydroxide (20 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (20 ml) and acidified to pH=2 using 2M hydrochloric acid. The mixture was extracted with ethyl acetate (100 ml), dried over sodium sulphate and evaporated in vacuo to give the title compound (1.7 g) as a white solid.
후처리
- customThe solvent was removed in vacuo
- extractionThe mixture was extracted with ethyl acetate (100 ml)
- dry with materialdried over sodium sulphate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-6b83f6d9aaa045038bfc47988077297a
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08658635B2
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