Sodium Hydroxide → HCID 58356418, 화합물

HRID 244672노트

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HRID 244672 반응식
[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([O:12]CC)=[O:11])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 50998908Ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate

생성물 1

HCID 58356418HCID 58356418, 화합물수율 33.8%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
20 °C

실험 절차

To a solution of ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate (75 mg) (available from Butt Park Ltd.) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the mixture taken up in water (5 ml) and acidified to pH=2 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and the mixture evaporated to give the title compound (22 mg) as a yellow solid.

후처리

  1. customThe solvent was removed in vacuo
  2. extractionthen extracted with ethyl acetate (20 ml)
  3. dry with materialdried over sodium sulphate
  4. customthe mixture evaporated

출처 및 근거

ORD 기록
ord-8bbcfc82b78140c4bbd1c49bf688d83e
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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