Sodium Hydroxide → 1-(propan-2-yl)-1H-1,2,3-triazole-5-carboxylic acid

HRID 244676노트

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HRID 244676 반응식
[CH3:1][CH:2]([N:4]1[C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([N:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:1]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58356337HCID 58356337, 화합물

생성물 1

HCID 583564111-(propan-2-yl)-1H-1,2,3-triazole-5-carboxylic acid수율 75%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
20 °C

실험 절차

To a solution of ethyl 1-(1-methylethyl)-1H-1,2,3-triazole-5-carboxylate (0.315 g) in methanol (5 ml) was added sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (5 ml) and acidified with 2M hydrochloric acid. The mixture was extracted with ethyl acetate and dried over sodium sulphate then filtered and evaporated to give the title compound (0.2 g) a white solid.

후처리

  1. customThe solvent was removed in vacuo
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over sodium sulphate
  4. filtrationthen filtered
  5. customevaporated

출처 및 근거

ORD 기록
ord-d6c5aaab542c4a5da21d5228117558be
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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