Hydrochloric Acid → N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

HRID 244682노트

반응식

HRID 244682 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:8]=[C:9]([NH2:14])[C:10]([CH3:13])=[N:11][CH:12]=1.Cl.C(Cl)Cl>N1C=CC=CC=1>[Br:6][C:7]1[CH:8]=[C:9]([NH:14][S:2]([CH3:1])(=[O:4])=[O:3])[C:10]([CH3:13])=[N:11][CH:12]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6344Dichloromethane2회HCID 31297Methanesulfonyl chlorideHCID 219640965-Bromo-2-methylpyridin-3-amine

생성물 1

HCID 57545815N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulfonyl chloride (97 μl) was added dropwise to 5-bromo-2-methyl-3-pyridinamine (Chempacific) (200 mg) in pyridine (5 ml). The reaction was stirred at room temperature for 20 min before addition of 2M HCl (aq) (5 ml) and extraction into DCM. The DCM was passed through a hydrophobic frit then dried under a stream of nitrogen. The residue was dissolved in DCM and washed through an aminopropyl cartridge (preconditioned with DCM) with DCM to give title compound, 77 mg.

후처리

  1. customthen dried under a stream of nitrogen
  2. dissolutionThe residue was dissolved in DCM
  3. washwashed through an aminopropyl cartridge (preconditioned with DCM) with DCM

출처 및 근거

ORD 기록
ord-afed0135a8b140f4b318f91a730a886e
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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