Water → 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid

HRID 24474

반응식

HRID 24474 반응식
C([O:3][C:4]([C:6]1[C:10]([CH2:11][CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])=[C:9]([CH:17]=[O:18])[NH:8][C:7]=1[CH3:19])=[O:5])C.[OH-].[Na+].O>CO.CCOC(C)=O>[CH3:16][N:14]([CH3:15])[CH2:13][CH2:12][CH2:11][C:10]1[C:6]([C:4]([OH:5])=[O:3])=[C:7]([CH3:19])[NH:8][C:9]=1[CH:17]=[O:18]

참가 물질

6

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 542399104-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

생성물 1

HCID 225710744-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid수율 94%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (300 mg, 1.13 mmol) and sodium hydroxide in MeOH (4 mL)/water (2 mL) was stirred at 80° C. for 19 hr. The reaction was then diluted with EtOAc. The aqueous layer was separated, neutralized and concentrated. The residue was dissolved in MeOH, filtered and the filtrate was concentrated to give 251 mg (94%) of 4-(3-dimethylaminopropyl)-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid.

후처리

  1. customThe aqueous layer was separated
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in MeOH
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-09f8ae93ec8949f8bb20561776aa5c9c
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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