D-Phenylalanine → HCID 178448095, 화합물

HRID 245348노트

반응식

HRID 245348 반응식
[CH:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10](Cl)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[NH2:13][C@@H:14]([C:22]([OH:24])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[CH3:2][CH:1]([CH3:3])[C@@H:4]1[CH2:9][CH2:8][C@@H:7]([C:10]([NH:13][C@H:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:22]([OH:24])=[O:23])=[O:11])[CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 71567D-PhenylalanineHCID 178448093HCID 178448093, 화합물

생성물 1

HCID 178448095HCID 178448095, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

EP1334963A discloses a method for producing nateglinide crystals from a reaction mixture containing nateglinide. The nateglinide is obtained by reacting trans-4-isopropylcyclohexane carboxylic acid chloride with D-phenylalanine in a mixed solvent of a ketone and water in the presence of an alkali, followed by neutralisation with an acid. Specific adjustment of the temperature of the mixture and the concentration of ketone solvent results in precipitation of nateglinide crystals. The ketone solvent(s) in the reaction is usually essential to proceed the reaction. However, a large quantity of acetone in the reaction causes high proportion of by-product.

출처 및 근거

ORD 기록
ord-e4967e728f3f48cfb34803717d20403b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658821B2

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