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Sodium hydride → ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate

HRID 245451
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HRID 245451 반응식
[H-].[Na+].[Si:3]([O:20][CH2:21][C:22]1[C:23]([N:38]2[CH2:43][C@H:42]([CH3:44])[O:41][C@H:40]([CH3:45])[CH2:39]2)=[C:24]([F:37])[C:25](F)=[C:26]([C:28](=[N:34][OH:35])[C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH:27]=1)([C:16]([CH3:19])([CH3:18])[CH3:17])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CN(C=O)C>[Si:3]([O:20][CH2:21][C:22]1[C:23]([N:38]2[CH2:43][C@H:42]([CH3:44])[O:41][C@H:40]([CH3:45])[CH2:39]2)=[C:24]([F:37])[C:25]2[O:35][N:34]=[C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:26]=2[CH:27]=1)([C:16]([CH3:17])([CH3:18])[CH3:19])([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 24758Sodium hydrideHCID 86658093Ethyl 2-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2-(hydroxyimino)acetate2회

생성물 1

HCID 67357675ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate수율 66.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매
2회

실험 절차

Sodium hydride (0.159 g, 3.97 mmol) was suspended in 20 ml of DMF and cooled in an ice bath. Ethyl 2-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2-(hydroxyimino)acetate (Intermediate 165, 1.94 g, 3.18 mmol) was dissolved in 20 ml of DMF and added to the reaction flask. The ice bath was removed and the reaction stirred at room temperature for 2 hours. The reaction was quenched with sat NH4Cl (5 ml), diluted with water and extracted three times with ethyl acetate. The organic layers were combined, washed with water and brine 5×, dried over MgSO4 and concentrated. The residue was purified by silica gel column chromatography using a gradient of hexanes to ethyl acetate to give the title compound (1.250 g, 66.6%).

후처리

  1. temperaturecooled in an ice bath
  2. additionadded to the reaction flask
  3. customThe ice bath was removed
  4. customThe reaction was quenched with sat NH4Cl (5 ml)
  5. additiondiluted with water
  6. extractionextracted three times with ethyl acetate
  7. washwashed with water and brine 5×
  8. dry with materialdried over MgSO4
  9. concentrationconcentrated
  10. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-4791e6b8174f4b8cb05ea97524bcb13c
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08658641B2

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