Ethyl 3-(bromophenyl)acetate → Ethyl 4-(3-bromophenyl)butanoate

HRID 24565

반응식

HRID 24565 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1.[Br:16]C1C=C(CC(OCC)=O)C=CC=1>>[Br:16][C:3]1[CH:4]=[C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:2]=1

참가 물질

3

반응물 2

HCID 11470552Ethyl 3-(bromophenyl)acetate2회HCID 12870375Ethyl 4-(4-bromophenyl)butanoate2회

생성물 1

HCID 11492759Ethyl 4-(3-bromophenyl)butanoate

실험 절차

Employing the same general multistep preparation as for ethyl 4-(4-bromophenyl)butanoate (Compound C), 60 g (246 mmol) of ethyl (3-bromophenyl)acetate (Compound B) was converted into the title compound (oil) using 255 ml (255 mmol) of diisobutylaluminum hydride (DIBAl—H, 1M in hexane), 85.8 g (250 mmol) of (carbethoxymethylene)triphenylphosphorane and 1.7 g of 10% Pd/C.

출처 및 근거

ORD 기록
ord-bc40a9034acc40c2b93dfccab2c8cce2
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855832B2

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