Hydrochloric Acid → 1-Oxazol-2-yl-ethylamine dihydrochloride

HRID 245892노트

반응식

HRID 245892 반응식
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([NH:8]S(C(C)(C)C)=O)[CH3:7].[ClH:15]>CO>[ClH:15].[ClH:15].[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([NH2:8])[CH3:7]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 712881642-Methyl-N-[1-(2-oxazolyl)ethyl]-2-propanesulfinamide

생성물 1

HCID 866779151-Oxazol-2-yl-ethylamine dihydrochloride수율 114.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a round-bottomed flask, 2-methyl-propane-2-sulfinic acid (1-oxazol-2-yl-ethyl)-amide (449 mg, 1.97 mmol) was dissolved in methanol (3.5 ml) and hydrogen chloride (4.0 M in 1,4-dioxane, 1.0 ml, 4.0 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 15 min then concentrated to give 417 mg of 1-oxazol-2-yl-ethylamine dihydrochloride as an orange waxy solid which was used without further purification.

후처리

  1. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-93f7639955474e3980659f1f26403da5
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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