Hydrochloric Acid → (R)-1-(4-trifluoromethylpyridin-2-yl)-ethylamine dihydrochloride

HRID 246015노트

반응식

HRID 246015 반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C@H:9]([NH:11][S@@](C(C)(C)C)=O)[CH3:10])[CH:4]=1.[ClH:20].O1CCOCC1>CO>[ClH:20].[ClH:20].[F:18][C:2]([F:1])([F:19])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C@H:9]([NH2:11])[CH3:10])[CH:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71288258(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethyl]-amide

생성물 1

HCID 86677935(R)-1-(4-trifluoromethylpyridin-2-yl)-ethylamine dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethyl]-amide (225 mg, 0.76 mmol) in MeOH (4 mL) was added 4.0 M hydrogen chloride in dioxane (0.48 mL, 1.9 mmol). The reaction mixture was stirred at room temperature for 30 min then concentrated and dried under high vacuum to afford 225 mg of (R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethylamine dihydrochloride as a viscous colorless oil which was used without further purification.

후처리

  1. concentrationthen concentrated
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-fd2010156f404f32b97ee332e31151cc
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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