Diisopropylethylamine → 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (S)-N-(tetrahydro-pyran-3-yl)-amide

반응식

FC(F)(F)C(O)=O.[O:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH2:14])[CH2:9]1.[Cl:15][C:16]1[CH:24]=[C:23]2[C:19]([C:20]([C:26]3[N:27]=[C:28]4[C:34]([C:35](O)=[O:36])=[CH:33][N:32]([CH2:38][O:39][CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[C:29]4=[N:30][CH:31]=3)=[N:21][N:22]2[CH3:25])=[CH:18][CH:17]=1.F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1.C(N(CC)C(C)C)(C)C>C(#N)C.C(OCC)(=O)C.O>[O:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][C:35]([C:34]2[C:28]3[C:29](=[N:30][CH:31]=[C:26]([C:20]4[C:19]5[C:23](=[CH:24][C:16]([Cl:15])=[CH:17][CH:18]=5)[N:22]([CH3:25])[N:21]=4)[N:27]=3)[N:32]([CH2:38][O:39][CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[CH:33]=2)=[O:36])[CH2:9]1