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1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → Methyl [[4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetate

HRID 24620
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HRID 24620 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([OH:16])=O)=[C:12]([CH3:17])[NH:11][C:10](=[O:18])[NH:9]2)[CH:5]=[CH:6][CH:7]=1.[C:19]1([CH:25]=[CH:26][CH2:27][NH:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([N:28]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[CH2:27][CH:26]=[CH:25][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])=[C:12]([CH3:17])[NH:11][C:10](=[O:18])[NH:9]2)[CH:5]=[CH:6][CH:7]=1
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참가 물질

5

반응물 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 225701824-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acidHCID 73192259Methyl (3-phenyl-2-propene-1-ylamino)acetate

생성물 1

HCID 73704953Methyl [[4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl]-(3-phenyl-2-propene-1-yl)-amino]acetate

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

320 mg (1.20 mmol) of 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid was dissolved in 2 ml of DMF. 280 mg (1.20 mmol) of methyl (3-phenyl-2-propene-1-ylamino)acetate and 276 mg (1.44 mmol) of WSC hydrochloride were added to the obtained solution, and they were stirred at room temperature overnight. After the extraction with ethyl acetate, the extract was dried over magnesium sulfate. Ethyl acetate was evaporated under reduced pressure. The residue was purified by the silica gel chromatography (methylene chloride/methanol=200/1 to 50/1) to obtain the title compound.

후처리

  1. extractionAfter the extraction with ethyl acetate
  2. dry with materialthe extract was dried over magnesium sulfate
  3. customEthyl acetate was evaporated under reduced pressure
  4. customThe residue was purified by the silica gel chromatography (methylene chloride/methanol=200/1 to 50/1)

출처 및 근거

ORD 기록
ord-340f1e4a03784978b9a0f3a072be0463
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06855716B2

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