Hydrochloric Acid → (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

HRID 246552

반응식

HRID 246552 반응식
C(OC(=O)[NH:7][C@H:8]([C:10]1[NH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][N:14]=1)[CH3:9])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[F:18][C:15]([F:16])([F:17])[C:12]1[NH:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:14][CH:13]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 71280415(S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate

생성물 1

HCID 71279885(S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of [(S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (50 mg, 179 μmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 15 h. The mixture was concentrated in vacuo then triturated with ether to give (S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethylamine hydrochloride (35 mg, quantitative) as a yellow oil. LCMS, [M+H]=180.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customthen triturated with ether

출처 및 근거

ORD 기록
ord-88c914026c9440bfbb921eb358b02c00
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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