Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 246804

반응식

HRID 246804 반응식
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324, 화합물

생성물 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide수율 70%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 42 g (0.5 mole) of cyanoguanidine ("dicyandiamide") and 50 g (0.5 mole) of 2,4-pentanedione ("acetylacetone") is heated at 120° C. for 15 hours. After the reaction mixture has cooled, 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product thereby obtained as crystals is isolated by filtration with suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

후처리

  1. temperatureAfter the reaction mixture has cooled
  2. customThe product thereby obtained as crystals
  3. customis isolated by filtration with suction

출처 및 근거

ORD 기록
ord-1ec1e42527784152a02fb76cd658dd51
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04704158

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