Benzyl Chloride → 5-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene

HRID 246847

반응식

HRID 246847 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-:10])=[O:9].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:13]([O:12][C:4]1[CH:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 1384663,5-Dimethyl-4-nitrophenol

생성물 1

HCID 133699565-(Benzyloxy)-1,3-dimethyl-2-nitrobenzene수율 84.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3,5-dimethyl-4-nitrophenol (17.6 g), benzyl chloride (20.0 g) and anhydrous K2CO3 (13.2 g) in acetone (100 ml) is stirred under reflux for 22 hours. The reaction mixture is filtered and the precipitate washed with acetone. The acetone extract is concentrated in vacuo and the residue short path distilled (160°-170° C.; 50μ) to give 22.9 grams of an orange liquid which crystallized on standing.

후처리

  1. temperatureunder reflux for 22 hours
  2. filtrationThe reaction mixture is filtered
  3. washthe precipitate washed with acetone
  4. extractionThe acetone extract
  5. concentrationis concentrated in vacuo
  6. distillationthe residue short path distilled (160°-170° C.; 50μ)

출처 및 근거

ORD 기록
ord-771e103ba1a248bea994b0162b26dd0b
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04704401

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