Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine

HRID 24706

반응식

HRID 24706 반응식
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[CH2:12]Cl>C1COCC1>[CH3:18][O:17][C:15]1[CH:14]=[C:11]([CH2:12][N:1]2[CH2:6][CH2:5][S:4][CH2:3][CH2:2]2)[CH:10]=[C:9]([O:8][CH3:7])[CH:16]=1

참가 물질

4

반응물 2

HCID 67164ThiomorpholineHCID 27583953,5-Dimethoxybenzyl chloride

생성물 1

HCID 7560214-(3,5-Dimethoxybenzyl)thiomorpholine수율 73.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).

후처리

  1. customThe solid material was removed by filtration
  2. customthe filtrate was evaporated
  3. customThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)

출처 및 근거

ORD 기록
ord-d8bd3fe4ea95445aa9547aebb5a6afed
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855843B2

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