Thiomorpholine → 4-(3,5-Dimethoxybenzyl)thiomorpholine
반응식
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[CH2:12]Cl>C1COCC1>[CH3:18][O:17][C:15]1[CH:14]=[C:11]([CH2:12][N:1]2[CH2:6][CH2:5][S:4][CH2:3][CH2:2]2)[CH:10]=[C:9]([O:8][CH3:7])[CH:16]=1참가 물질
4
실험 절차
Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).
후처리
- customThe solid material was removed by filtration
- customthe filtrate was evaporated
- customThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)
출처 및 근거
- ORD 기록
- ord-d8bd3fe4ea95445aa9547aebb5a6afed
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06855843B2
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