Sodium Hydroxide → HCID 178433474, 화합물

HRID 247267노트

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HRID 247267 반응식
[OH-].[Na+].[OH:3][C:4]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[Cl:14][O-].[Na+]>O>[Cl:14][C:10]1[CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]([OH:3])=[N:12][C:11]=1[CH3:13]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 23665760Sodium HypochloriteHCID 178425908HCID 178425908, 화합물

생성물 1

HCID 178433474HCID 178433474, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 15.7 g of 50% sodium hydroxide and 18.2 ml of water was added 10 g (0.065 mole) of 2-hydroxy-6-methylnicotinic acid. When the acid had dissolved, 200 ml of 5.25% aqueous sodium hypochlorite was added rapidly through a dropping funnel. The temperature was not moderated (slight exotherm did occur). The entire mixture was stirred at room temperature for 18 hr. The reaction mixture was then filtered and acidified with concentrated hydrochloric acid. The precipitate was recrystallized from isopropyl alcohol/ethereal to give ~6 g of analytically pure crystals, m.p. 291°-94° C.

후처리

  1. dissolutionWhen the acid had dissolved
  2. filtrationThe reaction mixture was then filtered
  3. customThe precipitate was recrystallized from isopropyl alcohol/ethereal
  4. customto give ~6 g of analytically pure crystals, m.p. 291°-94° C.

출처 및 근거

ORD 기록
ord-608af73f5b864975b54fddea2afedb6a
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04705853

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