3-(3,5-Difluorophenyl)acrylic acid → 3-(3,5-Difluorophenyl)propionic acid

HRID 247415

반응식

HRID 247415 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.[H][H]>O1CCCC1.[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

6

반응물 2

HCID 5228103-(3,5-Difluorophenyl)acrylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 36694983-(3,5-Difluorophenyl)propionic acid수율 99%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 3-(3,5-difluorophenyl)propenoic acid (0.0435 mol) in tetrahydrofuran (100 ml) and a slurry of 10% palladium on carbon (1.5 g) in ethyl acetate were shaken together under 50 psi hydrogen for 4 hours. The mixture was filtered and concentrated to yield 8 g (99%) of a yellow oil.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d9ae1a7a367840edaf522e00b5698f79
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707488

연결된 노트

불러오는 중…