Methanol → 3-(3,5-Difluorophenyl)propan-1-ol

HRID 247416

반응식

HRID 247416 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11](O)=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.CO>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][OH:12])[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 36694983-(3,5-Difluorophenyl)propionic acid

생성물 1

HCID 140499113-(3,5-Difluorophenyl)propan-1-ol수율 95%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Borane-tetrahydrofuran complex (0.095 mol) was added to a cooled (0°) solution of 3-(3,5-difluorophenyl)propanoic acid (0.043 mol) in tetrahydrofuran (75 ml). The reaction was stirred 2 hours at room temperature, then methanol was carefully added and the reaction was concentrated. The crude product was dissolved in ethyl ether, washed with water, dried over sodium sulfate and concentrated to yield 7 g (95%) of an oily product.

후처리

  1. additionBorane-tetrahydrofuran complex (0.095 mol) was added to
  2. concentrationthe reaction was concentrated
  3. dissolutionThe crude product was dissolved in ethyl ether
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b6d710202a124d13b938d890da0e0c2b
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707488

연결된 노트

불러오는 중…