Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-(3,5-Difluorophenyl)propan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 3-(3,5-Difluorophenyl)propionic acid | HCID 3669498 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(3,5-Difluorophenyl)propan-1-ol | HCID 14049911 | 95% |
반응 단계
Borane-tetrahydrofuran complex (0.095 mol) was added to a cooled (0°) solution of 3-(3,5-difluorophenyl)propanoic acid (0.043 mol) in tetrahydrofuran (75 ml). The reaction was stirred 2 hours at room temperature, then methanol was carefully added and the reaction was concentrated. The crude product was dissolved in ethyl ether, washed with water, dried over sodium sulfate and concentrated to yield 7 g (95%) of an oily product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04707488 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-b6d710202a124d13b938d890da0e0c2b |
| 출처 메모 | uspto-grants-1987_11 |