反应详情

Borane-tetrahydrofuran complex (0.095 mol) was added to a cooled (0°) solution of 3-(3,5-difluorophenyl)propanoic acid (0.043 mol) in tetrahydrofuran (75 ml). The reaction was stirred 2 hours at room temperature, then methanol was carefully added and the reaction was concentrated. The crude product was dissolved in ethyl ether, washed with water, dried over sodium sulfate and concentrated to yield 7 g (95%) of an oily product.

1. additionBorane-tetrahydrofuran complex (0.095 mol) was added to
2. concentrationthe reaction was concentrated
3. dissolutionThe crude product was dissolved in ethyl ether
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated