3-Chloro-1,2-propanediol → 3-[p-(2,3-Dihydroxypropoxy)benzoyl]indole

HRID 247557노트

반응식

HRID 247557 반응식
[OH:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:22][CH:23]([OH:26])[CH2:24][OH:25]>O>[OH:26][CH:23]([CH2:24][OH:25])[CH2:22][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[O:7])=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 72903-Chloro-1,2-propanediolHCID 14798Sodium HydroxideHCID 30626713-(p-Hydroxy)benzoyl indole

생성물 1

HCID 136694903-[p-(2,3-Dihydroxypropoxy)benzoyl]indole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

11 g of 3-(p-hydroxybenzoyl)indole and 7.43 g of sodium hydroxide were dissolved in 10 ml of water. 20.51 g of 3-chloro-1,2-propandiol was added to the solution followed by reflux with stirring for 3 hours in oil bath. After cooling, the solution was evaporated to dryness. The residue was purified by column chromatography on silica gel. After recrystallization from ethyl acetate, 3-[p-(2,3-dihydroxypropoxy)benzoyl]indole (compound 16) was obtained in the form of white crystals. (Yield: 13.8%).

후처리

  1. temperatureby reflux
  2. temperatureAfter cooling
  3. customthe solution was evaporated to dryness
  4. customThe residue was purified by column chromatography on silica gel
  5. customAfter recrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-0832719b940f4026b165b37c2b01e781
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04708961

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