2,3-Butanediamine → N-(2-amino-1-methylpropyl)-5-isoquinolinesulfonamide

HRID 247583

반응식

HRID 247583 반응식
[NH2:1][CH:2]([CH:4]([NH2:6])[CH3:5])[CH3:3].[CH:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([S:17](Cl)(=[O:19])=[O:18])[C:11]=2[CH:10]=[CH:9][N:8]=1>C(Cl)(Cl)Cl>[NH2:1][CH:2]([CH3:3])[CH:4]([NH:6][S:17]([C:12]1[C:11]2[CH:10]=[CH:9][N:8]=[CH:7][C:16]=2[CH:15]=[CH:14][CH:13]=1)(=[O:18])=[O:19])[CH3:5]

참가 물질

4

반응물 2

HCID 1363622,3-ButanediamineHCID 33716555-Isoquinolinesulfonyl chloride

생성물 1

HCID 20159892N-(2-amino-1-methylpropyl)-5-isoquinolinesulfonamide수율 80%

시약·촉매·용매 1

HCID 6212Chloroform용매4회

실험 절차

In 100 ml of chloroform was dissolved 12.9 g of 2,3-diaminobutane and to the solution was added dropwise 10 ml of a chloroform solution containing 4.0 g of 5-isoquinolinesulfonyl chloride under cooling with ice. After the dropwise addition of the chloroform solution, the mixed solution was stirred at a temperature of 20° C. to 25° C. for two hours, and the reaction mixture solution was washed with water and dried with anhydrous sodium carbonate. The chloroform was distilled therefrom under reduced pressure, and the residue thus obtained was subjected to a column chromatography [silica gel: 160 g; solvent: chloroform] to give 3.92 g of N-(2-amino-1-methylpropyl)-5-isoquinolinesulfonamide in a yield of 80%.

후처리

  1. temperatureunder cooling with ice
  2. washthe reaction mixture solution was washed with water
  3. dry with materialdried with anhydrous sodium carbonate
  4. distillationThe chloroform was distilled
  5. customunder reduced pressure, and the residue thus obtained

출처 및 근거

ORD 기록
ord-af05719e99bc4905b99766affd96dcba
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709032

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