Succinimide → N-(2-cycloheptenyl)succinimide
반응식
Br[CH:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]=[CH:3]1.[C:9]1(=[O:15])[NH:13][C:12](=[O:14])[CH2:11][CH2:10]1.[Na].C1(=O)NC(=O)CC1.[H-].[Na+]>O.CN(C=O)C>[CH:2]1([N:13]2[C:9](=[O:15])[CH2:10][CH2:11][C:12]2=[O:14])[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]=[CH:3]1참가 물질
7
실험 절차
3-Bromocycloheptene (1.75 g) was added dropwise at room temperature to a DMF suspension (10 ml) of sodium succinimide prepared from succinimide (0.99 g) and 60% sodium hydride (0.40 g). This mixture was stirred at room temperature for 24 hours, poured into water (10 ml) and extracted with ether. The oily product obtained by concentration was purified by chromatography on silica gel to obtain 0.09 g of N-(2-cycloheptenyl)succinimide [Compound (214)].
후처리
- extractionextracted with ether
- customThe oily product obtained by concentration
- customwas purified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-76c9c1ca543841c883d77550d87dbfde
- 출처 데이터셋
- uspto-grants-1987_11
- 특허 번호
- US04709052
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