Acetone → 1,2:3,4:5,6-Tris-O-(1-methylethylidene)hexitol

HRID 247639

반응식

HRID 247639 반응식
[CH2:1]([OH:12])[C@H:2]([C@H:4]([C@@H:6]([C@@H:8]([CH2:10][OH:11])[OH:9])[OH:7])[OH:5])[OH:3].[CH3:13][C:14]([CH3:16])=O>>[CH3:13][C:14]1([CH3:16])[O:9][CH:8]([CH:6]2[O:7][C:2]([CH3:4])([CH3:1])[O:5][CH:4]2[CH:2]2[O:3][C:8]([CH3:10])([CH3:6])[O:12][CH2:1]2)[CH2:10][O:11]1

참가 물질

3

반응물 2

HCID 180AcetoneHCID 6251Mannitol

생성물 1

HCID 3165221,2:3,4:5,6-Tris-O-(1-methylethylidene)hexitol

실험 절차

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol is prepared by rapidly stirring with a mechanical stirrer, of 40 g of mannitol and 500 ml of anhydrous acetone in the presence of 4.0 ml of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask. The sulfuric acid is neutralized with about 6.8 g anhydrous sodium carbonate and the acetone is evaporated by vacuum distillation at about 30° C. The remaining yellowish oil is diluted with an equal volume of cold water in order to provide the crystalline product. The crystals are filtered, dried, and used without further purification.

후처리

  1. concentrationof concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask
  2. customthe acetone is evaporated by vacuum distillation at about 30° C
  3. additionThe remaining yellowish oil is diluted with an equal volume of cold water in order
  4. customto provide the crystalline product
  5. filtrationThe crystals are filtered
  6. customdried
  7. customused without further purification

출처 및 근거

ORD 기록
ord-5e48a3d4b11b49e5841c760cbf362875
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709059

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