Styrene → Ethyl 2-phenylcyclopropane-1-carboxylate

HRID 247735

반응식

HRID 247735 반응식
[CH2:1]=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N+](=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N-]>C(Cl)Cl>[C:3]1([CH:2]2[CH2:1][CH:11]2[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 7501Styrene2회HCID 12192Ethyl diazoacetate2회

생성물 1

HCID 316914Ethyl 2-phenylcyclopropane-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of CH2Cl2 (12.5 mL), styrene (12 5 mL) and ethyl diazoacetate (0.25 g, 2.19 mmol) was added slowly dropwise at ambient temperature to a stirred slurry of Rh-PFIEP[SO3H] (1.0 g, 0.387 mmol, prepared as described above), styrene (2.5 mL) and CH2Cl2 (2.5 mL). Gas evolution ceased about 1 hour after the addition of the ethyl diazoacetate solution was complete. The resulting slurry was stirred for 24 hours and then allowed to settle. The solution was removed, the resulting resin was washed with 3.0 mL of CH2Cl2. The solution and the wash were combined and analyzed for cyclopropane products. Yield (based on ethyl diazoacetate): 73.9%.

후처리

  1. customThe solution was removed
  2. washthe resulting resin was washed with 3.0 mL of CH2Cl2
  3. customYield (based on ethyl diazoacetate)

출처 및 근거

ORD 기록
ord-137bc18394124147bbbd48a0e5264ee2
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709085

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