Hydrochloric Acid → 2-Naphthalenecarboxylic acid, 6-(decyloxy)-

HRID 247795

반응식

HRID 247795 반응식
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[OH:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:23]([OH:25])=[O:24])[CH:19]=2)[CH:14]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O.O.C(OCC)C>[CH2:1]([O:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:23]([OH:25])=[O:24])[CH:19]=2)[CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 81731-BromodecaneHCID 11430Potassium CarbonateHCID 855576-Hydroxy-2-naphthoic acid

생성물 1

HCID 103591672-Naphthalenecarboxylic acid, 6-(decyloxy)-수율 68.8%

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

After a solution of decylmonobromide (7 g), 2-hydroxy-6-carboxynaphthalene (2 g) and anhydrous potassium carbonate (4 g) in dimethylformamide (100 ml) was stirred at 130° C. for two hours, it was poured in water. Dilute aqueous hydrochloric acid solution was added thereto until the solution was neutral. To the solution was added diethylether in order to effect extraction. The extracted layer was distilled to remove the solvent. The residue was added to a solution of sodium hydroxide (3.3 g) in water (10 ml) and ethanol (50 ml). The mixture was refluxed for about one day. Thereto was added dilute aqueous hydrochloric acid solution until the solution was neutral. The solution was distilled to remove the solvent and concentrated. Solid precipitate was collected and recrystallized from water-ethanol mixture to obtain the titled compound (2.4 g).

후처리

  1. extractionextraction
  2. distillationThe extracted layer was distilled
  3. customto remove the solvent
  4. additionThe residue was added to a solution of sodium hydroxide (3.3 g) in water (10 ml) and ethanol (50 ml)
  5. temperatureThe mixture was refluxed for about one day
  6. additionThereto was added dilute aqueous hydrochloric acid solution until the solution
  7. distillationThe solution was distilled
  8. customto remove the solvent
  9. concentrationconcentrated
  10. customSolid precipitate was collected
  11. customrecrystallized from water-ethanol mixture

출처 및 근거

ORD 기록
ord-809580bbbd2741c2beaa3b6776424a4d
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05207947

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