4-Hydroxybenzoic Acid → 4-(Octyloxy)benzoic acid

HRID 247798

반응식

HRID 247798 반응식
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O.O.C(OCC)C>[CH2:1]([O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

8

반응물 4

HCID 1354-Hydroxybenzoic AcidHCID 313Hydrochloric Acid2회HCID 81401-BromooctaneHCID 11430Potassium Carbonate

생성물 1

HCID 172314-(Octyloxy)benzoic acid수율 71.4%

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

A solution of octylbromide (4.19 g), 4-hydroxybenzoic acid (3 g) and potassium carbonate (3 g) in dimethylformamide (100 ml) was stirred at 130° C. for two hours. The solution was poured in water and neutralized with dilute aqueous hydrochloric acid solution. Diethylether was added to effect extraction. After the extracted layer was distilled to remove the solvent, the residue was added to a solution of sodium hydroxide (3.3 g), water (10 ml) and ethanol (50 ml). The solution obtained was refluxed for about a day and neutralized with dilute aqueous hydrochloric acid solution. The solution was distilled to remove the solvent and concentrated. The solid obtained was collected and recrystallized from water/ethanol to obtain the titled compound (3.88 g).

후처리

  1. distillationAfter the extracted layer was distilled
  2. customto remove the solvent
  3. additionthe residue was added to a solution of sodium hydroxide (3.3 g), water (10 ml) and ethanol (50 ml)
  4. customThe solution obtained
  5. distillationThe solution was distilled
  6. customto remove the solvent
  7. concentrationconcentrated
  8. customThe solid obtained
  9. customwas collected
  10. customrecrystallized from water/ethanol

출처 및 근거

ORD 기록
ord-4ec4327d040a4a578173b0f6893bc343
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05207947

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