Diisopropylaniline → Acetamide, N-[2,6-bis(1-methylethyl)phenyl]-2-bromo-

HRID 247836

반응식

HRID 247836 반응식
[CH:1]([C:4]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]([CH3:13])[CH3:12])[C:5]=1[NH2:6])([CH3:3])[CH3:2].O.O.O.C([O-])(=O)C.[Na+].[Br:22][CH2:23][C:24](Br)=[O:25]>CC(C)=O.O>[CH3:12][CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5]=1[NH:6][C:24](=[O:25])[CH2:23][Br:22])[CH3:13]

참가 물질

6

반응물 3

HCID 32484DiisopropylanilineHCID 61147Bromoacetyl bromideHCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 12149064Acetamide, N-[2,6-bis(1-methylethyl)phenyl]-2-bromo-수율 86.8%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매2회

실험 절차

To a well-stirred ice-cooled mixture of 2,6-diisopropylaniline (10.0 g, 0.056 mol) in acetone (25 mL) and water (25 mL) and sodium acetate trihydrate (15.3 g, 0.112 mol), bromoacetyl bromide (17.0 g, 0.084 mol) is added dropwise. The reaction mixture is allowed to warm to room temperature and stirred for 1 hour. The reaction mixture is diluted with water (100 mL), the product filtered, washed with cold water, sodium bicarbonate solution, water, and finally with hexane. The product is dried in a vacuum at 40° C. to afford 14.5 g of the title compound as a white solid; mp I70° C.

후처리

  1. additionis added dropwise
  2. filtrationthe product filtered
  3. washwashed with cold water, sodium bicarbonate solution, water
  4. customThe product is dried in a vacuum at 40° C.

출처 및 근거

ORD 기록
ord-d5a959fffbcc4c339707cebc8fa87a56
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208224

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