1-Methylhydantoin → 5-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-1-methyl-2,4-imidazolidinedione

반응식

[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[C:11]=1[OH:12])[CH:7]=O)([CH3:3])[CH3:2].[CH3:16][N:17]1[CH2:23][C:21](=[O:22])[NH:20][C:18]1=[O:19]>>[OH:12][C:11]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][C:6]([CH:7]=[C:23]2[N:17]([CH3:16])[C:18](=[O:19])[NH:20][C:21]2=[O:22])=[CH:9][C:10]=1[CH:13]([CH3:15])[CH3:14]

참가 물질

반응물 2

HCID 692171-Methylhydantoin

HCID 827124-Hydroxy-3,5-bis(isopropyl)benzaldehyde

생성물 1

HCID 542840515-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-1-methyl-2,4-imidazolidinedione수율 11%

실험 절차

Prepared according to the procedure described in Example 92 using 3,5-diisopropyl-4-hydroxybenzaldehyde (2.7 g, 13 mmoles) and 1-methyl hydantoin (1.4 g, 12 mmoles). Recrystallization from acetonitrile gave the pure product (0.4 g), mp 197°-208° C.

후처리

customPrepared
customRecrystallization from acetonitrile

출처 및 근거

ORD 기록: ord-aebed7088a92478092afa826da1265d1
출처 데이터셋: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05208250

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