Hydrochloric Acid → 4-(Tetradecyloxy)benzoic acid

HRID 247912

반응식

HRID 247912 반응식
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:6][CH:5]=1.[OH-].[K+].Cl>C(Cl)Cl.O.CO.C(O)C>[CH2:11]([O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:25])=[O:2])=[CH:9][CH:8]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

참가 물질

8

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 3312490Methyl 4-(tetradecyloxy)benzoate

생성물 1

HCID 2894104-(Tetradecyloxy)benzoic acid수율 99%

시약·촉매·용매 4

HCID 702Ethanol용매HCID 887Methanol용매2회HCID 962Water용매2회HCID 6344Dichloromethane용매

실험 절차

To 20 g of product from Example 1 is added 9.66 g potassium hydroxide, 160 ml methyl alcohol, 10 ml water and 70 ml ethyl alcohol. The reaction mixture is refluxed for 6.5 hours, during which time an additional 100 ml methyl alcohol and 100 ml water is added. To the cooled reaction mixture is added 1 L of methylene chloride and sufficient concentrated hydrochloric acid to make the reaction pH acidic. The white crystals are collected and dried in vacuo over phosphorus pentoxide to give 19.0 g of the desired product. MP 94°-96° C.

후처리

  1. additionis added
  2. customTo the cooled reaction mixture
  3. customThe white crystals are collected
  4. dry with materialdried in vacuo over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-1f1a5e5e33ab43668325737b19d38676
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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