Water → 2-Methoxy-N-(2-pyridinylmethyl)-N-[4-(tetradecyloxy)benzoyl]benzamide

HRID 247916

반응식

HRID 247916 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][C:9](=[O:31])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:12][CH:11]=1.[C:32](Cl)(=[O:41])[C:33]1[C:34]([O:39][CH3:40])=[CH:35][CH:36]=[CH:37][CH:38]=1.O>O1CCCC1.[H-].[Na+]>[CH3:40][O:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[C:32]([N:8]([CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:9](=[O:31])[C:10]1[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:14][CH:15]=1)=[O:41]

참가 물질

6

반응물 3

HCID 962WaterHCID 889692-Methoxybenzoyl chlorideHCID 10093859N-(2-Pyridinylmethyl)-4-(tetradecyloxy)benzamide

생성물 1

HCID 190164342-Methoxy-N-(2-pyridinylmethyl)-N-[4-(tetradecyloxy)benzoyl]benzamide수율 96.5%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 24758Sodium hydride용매

실험 절차

To a solution of 1 g of product from Example 4 in 15 ml of dry tetrahydrofuran is added in one portion 0.0622 g of sodium hydride. The mixture is heated at reflux temperature for 2 hours, cooled to room temperature and 0.442 g o-anisoyl chloride is added. The reaction is then heated at reflux for 1.5 hours, cooled to room temperature, poured into water and extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel: 35% ethyl acetate/hexane) to give 1.27 g of the desired product.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux temperature for 2 hours
  3. temperatureThe reaction is then heated
  4. temperatureat reflux for 1.5 hours
  5. temperaturecooled to room temperature
  6. extractionextracted with ethyl acetate
  7. washThe organic layer is washed with saturated sodium chloride
  8. customdried
  9. concentrationconcentrated in vacuo
  10. customThe residue is purified by column chromatography (silica gel: 35% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-ab919752fb384c5da7e745d191f91429
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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