Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 1-(Bromomethyl)-4-(tetradecyloxy)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | 4-Tetradecyloxybenzyl alcohol | HCID 10087384 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(Bromomethyl)-4-(tetradecyloxy)benzene | HCID 10022840 | 88.7% |
반응 단계
To a room temperature slurry of 2.5 g of product from Example 19, 10 ml of acetonitrile and 0.339 g of pyridine is added dropwise, over 3 minutes, 2.11 g of phosphorus tribromide. The reaction is stirred at room temperature for 1 hour, diluted with methylene chloride and concentrated in vacuo. The residue is dissolved in methylene chloride, filtered through a silica gel pad and concentrated in vacuo to give 2.65 g of the desired product as pale yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05208247 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-4d4f05d0770d4ec2b0f3bf0f9e2a5dfb |
| 출처 메모 | uspto-grants-1993_05 |