Oxalyl chloride → p-Tetradecyloxyphenylacetylchloride

HRID 247962

반응식

HRID 247962 반응식
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=O)=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C(Cl)(=O)C([Cl:29])=O>C(Cl)Cl.CN(C)C=O>[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([Cl:29])=[O:25])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 10472964p-Tetradecyloxyphenylacetic acid

생성물 1

HCID 10021844p-Tetradecyloxyphenylacetylchloride수율 100%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a mixture of 60.6 g of product from Example 52 in 750 ml of methylene chloride and 0.636 g of dimethylformamide is added, dropwise, 33.1 g of oxalyl chloride. The reaction is stirred at room temperature for 18 hours. The mixture is concentrated in vacuo, redissolved in diethyl ether, passed through a pad of diatomaceous earth and concentrated in vacuo to give 63.81 g of the desired product.

후처리

  1. additionis added
  2. concentrationThe mixture is concentrated in vacuo
  3. dissolutionredissolved in diethyl ether
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7dd389b6a302427da4a75e6d768645eb
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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