1H,3H-furo(3,4-c)pyridine-1,3-dione → 2-[[4-(Tetradecyloxy)phenyl]methyl]-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione

HRID 248026

반응식

HRID 248026 반응식
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][NH2:23])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[CH:24]1[C:29]2[C:30]([O:32][C:33](=O)[C:28]=2[CH:27]=[N:26][CH:25]=1)=[O:31]>C(Cl)(Cl)Cl>[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[C:30](=[O:31])[C:29]3[CH:24]=[CH:25][N:26]=[CH:27][C:28]=3[C:33]2=[O:32])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneHCID 117234984-(Tetradecyloxy)benzenemethanamine

생성물 1

HCID 197646812-[[4-(Tetradecyloxy)phenyl]methyl]-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione수율 88.5%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
190 °C

실험 절차

A mixture of 2.5 g of product from Example 99 and 1.17 g of 3,4-pyridinecarboxylic anhydride is heated, in a sealed tube, at 190° C. for 12 minutes. The cooled crystalline product is dissolved in chloroform, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue is purified by chromatography (silica gel: 30-40% ethyl acetate/hexane) to give 3.12 g of the desired product as colorless crystals.

후처리

  1. dry with materialdried over anhydrous sodium sulfate
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo
  4. customThe residue is purified by chromatography (silica gel: 30-40% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-3b3f8b7adafa4020a56596e78420f3bf
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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