참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethyl methylmalonate | HCID 11857 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Acetamide, N-(4-(chloromethyl)phenyl)- | HCID 148705 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Diethyl methyl-(4-acetamido)benzylmalonate | HCID 54008305 | — |
반응 단계
Suspend sodium hydride (10.1 g, 0.21 mol) in tetrahydrofuran (300 mL), place under a nitrogen atmosphere and cool to 0° C. Add, by dropwise addition, diethyl methylmalonate (34.8 g, 0.2 mol). Stir for 30 minutes at 0° C. and add 4-acetamidobenzyl chloride (38.6 g, 0.21 mol). Heat at reflux for 5 hours, cool and pour into water (400 mL). Extract with ethyl acetate (3×600 mL), dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-acetamido)benzylmalonate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05208240 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-b9fb229e404a4af4a10cf640f17b2088 |
|---|
| 출처 메모 | uspto-grants-1993_05 |
|---|
