反应详情

温度

0 °C

Suspend sodium hydride (10.1 g, 0.21 mol) in tetrahydrofuran (300 mL), place under a nitrogen atmosphere and cool to 0° C. Add, by dropwise addition, diethyl methylmalonate (34.8 g, 0.2 mol). Stir for 30 minutes at 0° C. and add 4-acetamidobenzyl chloride (38.6 g, 0.21 mol). Heat at reflux for 5 hours, cool and pour into water (400 mL). Extract with ethyl acetate (3×600 mL), dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-acetamido)benzylmalonate.

1. temperatureHeat
2. temperatureat reflux for 5 hours
3. temperaturecool
4. extractionExtract with ethyl acetate (3×600 mL)
5. dry with materialdry (MgSO4)
6. customevaporate the solvent in vacuo