Hydrochloric Acid → Diethyl methyl-(4-amino)benzylmalonate

HRID 248063노트

반응식

HRID 248063 반응식
[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.C(=O)([O-])O>>[CH3:1][C:2]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 54008305Diethyl methyl-(4-acetamido)benzylmalonate

생성물 1

HCID 54055855Diethyl methyl-(4-amino)benzylmalonate

실험 절차

Mix diethyl methyl-(4-acetamido)benzylmalonate (5.01 g, 15.6 mmol) and 2N hydrochloric acid (65 mL) and heat at reflux for several hours. Cool to room temperature, basify with solid hydrogen carbonate and extract into ethyl ether (3×). Dry (MgSO4) and evaporate the solvent in vacuo to give diethyl methyl-(4-amino)benzylmalonate.

후처리

  1. temperatureheat
  2. temperatureat reflux for several hours
  3. extractionextract into ethyl ether (3×)
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-05b0ce8b6270496ab4525a8a2b7e8ddd
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208240

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