Diazomethane → 4-[[2-(1,1-Dimethylethoxy)-2-oxoethyl]oxy]-alpha-methyl-benzenepropanoic acid, methyl ester

HRID 248078노트

반응식

HRID 248078 반응식
[CH3:1][C:2]([CH3:21])([O:4][C:5](=[O:20])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:19])[C:16]([OH:18])=[O:17])=[CH:10][CH:9]=1)[CH3:3].[N+](=[CH2:24])=[N-]>C(OCC)C>[CH3:3][C:2]([CH3:1])([O:4][C:5](=[O:20])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:19])[C:16]([O:18][CH3:24])=[O:17])=[CH:10][CH:9]=1)[CH3:21]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 197645314-[[2-(1,1-Dimethylethoxy)-2-oxoethyl]oxy]-alpha-methyl-benzenepropanoic acid

생성물 1

HCID 867467874-[[2-(1,1-Dimethylethoxy)-2-oxoethyl]oxy]-alpha-methyl-benzenepropanoic acid, methyl ester

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Dissolve (+)-4-[[2-(1,1-dimethylethoxy)-2-oxoethyl]oxy]-alpha-methyl-benzenepropanoic acid (90% ee) (6.04 g, 20.5 mmol) in ethyl ether (400 mL) and treat with excess diazomethane. Wash with saturated sodium hydrogen carbonate (2×300 mL) and brine (300 mL). Dry (MgSO4) and evaporate the solvent in vacuo to give (+)-4-[[2-(1,1-dimethylethoxy)-2-oxoethyl]oxy]-alpha-methyl-benzenepropanoic acid, methyl ester (5.85 g).

후처리

  1. washWash with saturated sodium hydrogen carbonate (2×300 mL) and brine (300 mL)
  2. dry with materialDry (MgSO4)
  3. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-cb03b59edc6f49b58f2d6387d49e8bb5
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208240

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