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N-bromobutanimide → 1-(Bromomethyl)-2-chloro-4-iodobenzene

HRID 248095
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인쇄 미리보기

반응식

HRID 248095 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([I:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:10]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:10][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([I:9])=[CH:3][C:2]=1[Cl:1]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 28013292-Chloro-4-iodotoluene

생성물 1

HCID 220586831-(Bromomethyl)-2-chloro-4-iodobenzene수율 93.1%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 3-chloro-4-methyliodobenzene (9.0 g), N-bromosuccinimide (8.5 g), benzoyl peroxide (0.3 g) and carbon tetrachloride (80 ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated to give 4-bromomethyl-3-chloroiodobenzene (11 g) which was used without further purification.

후처리

  1. temperatureheated
  2. temperatureto reflux for 3 hours
  3. filtrationfiltered
  4. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-935f0674609840a5b887ec8d5a6be8ee
출처 데이터셋
uspto-grants-1993_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05208259

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