Sodium Hydroxide → HCID 178521236, 화합물

HRID 24814노트

반응식

HRID 24814 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:16](OCC)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]1=[O:26])(=O)C.[O:27]1[CH2:32][CH2:31][N:30]([CH2:33][C:34]([NH:36][C:37]2[CH:43]=[CH:42][C:40]([NH2:41])=[CH:39][CH:38]=2)=[O:35])[CH2:29][CH2:28]1.[OH-].[Na+]>CN(C=O)C.CO>[O:27]1[CH2:28][CH2:29][N:30]([CH2:33][C:34]([NH:36][C:37]2[CH:43]=[CH:42][C:40]([NH:41]/[C:16](=[C:6]3\[C:5](=[O:26])[NH:4][C:12]4[C:7]\3=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=4)/[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:39][CH:38]=2)=[O:35])[CH2:31][CH2:32]1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 16227712N-(4-aminophenyl)-2-(morpholin-4-yl)acetamideHCID 542801041-Acetyl-3-{1-ethoxy-1-phenylmethylidene}-5-nitro-2-indolinone

생성물 1

HCID 178521236HCID 178521236, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 82 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 4-morpholinomethylcarbonylamino-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

출처 및 근거

ORD 기록
ord-3d96ec9d3a5140a4951d14927a26aaef
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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