Trimethyl orthovalerate → 2-butyl-1H-thieno[3,4-d]imidazole
반응식
[NH2:1][C:2]1[C:6]([NH2:7])=[CH:5][S:4][CH:3]=1.[C:8](OC)(OC)(OC)[CH2:9][CH2:10][CH2:11][CH3:12].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>C(O)C>[CH2:9]([C:8]1[NH:1][C:2]2=[CH:3][S:4][CH:5]=[C:6]2[N:7]=1)[CH2:10][CH2:11][CH3:12]참가 물질
5
실험 절차
To a solution of 3,4-diaminothiophene (156 mg) in ethanol (10 ml) was added trimethyl orthovalerate (0.29 ml) and pyridinium p-toluenesulfonate (4 mg). The mixture was refluxed for one hour and concentrated in vacuo. The residue was purified by preparative thin layer chromatography on silica gel developed by ethyl acetate to give 2-butyl-1H-thieno[3,4-d]imidazole (155 mg) as crystals.
후처리
- temperatureThe mixture was refluxed for one hour
- concentrationconcentrated in vacuo
- customThe residue was purified by preparative thin layer chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-354f919044724ce2b749849551db4a26
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05210092
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