Trimethyl orthovalerate → 2-butyl-1H-thieno[3,4-d]imidazole

HRID 248380

반응식

HRID 248380 반응식
[NH2:1][C:2]1[C:6]([NH2:7])=[CH:5][S:4][CH:3]=1.[C:8](OC)(OC)(OC)[CH2:9][CH2:10][CH2:11][CH3:12].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>C(O)C>[CH2:9]([C:8]1[NH:1][C:2]2=[CH:3][S:4][CH:5]=[C:6]2[N:7]=1)[CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 3

HCID 83755Trimethyl orthovalerateHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 643216Thiophene-3,4-diamine

생성물 1

HCID 193706342-butyl-1H-thieno[3,4-d]imidazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 3,4-diaminothiophene (156 mg) in ethanol (10 ml) was added trimethyl orthovalerate (0.29 ml) and pyridinium p-toluenesulfonate (4 mg). The mixture was refluxed for one hour and concentrated in vacuo. The residue was purified by preparative thin layer chromatography on silica gel developed by ethyl acetate to give 2-butyl-1H-thieno[3,4-d]imidazole (155 mg) as crystals.

후처리

  1. temperatureThe mixture was refluxed for one hour
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by preparative thin layer chromatography on silica gel

출처 및 근거

ORD 기록
ord-354f919044724ce2b749849551db4a26
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05210092

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