참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Benzene, 2,4-dichloro-1-fluoro- | HCID 123112 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 생성물 | Acetophenone, 2',4'-dichloro-5'-fluoro- | HCID 727250 | — |
반응 단계
A mixture of 229.6 g of 1,3-dichloro-4-fluorobenzene and 205.34 g of aluminum chloride was heated at 80° C. A 56 g portion of acetic anhydride was added dropwise over 2 hours, then the reaction ws heated at 100° C. for 8 hours, poured onto a mixture of concentrated hydrochloric acid and ice and extracted several times with ether. The ether extracts were combined, washed with water, dried and the solvents evaporated. The solid was purified by vacuum distillation, giving 156.63 g of 6-acetyl-1,3-dichloro-4-fluorobenzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05210193 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-37d187f7d13144d49ee81d90538374b3 |
|---|
| 출처 메모 | uspto-grants-1993_05 |
|---|
