Trityl chloride → 5-(4'-Methyl-(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole

HRID 248620노트

반응식

HRID 248620 반응식
C[Sn](C)(C)[N:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)=[N:6][N:5]=[N:4]1.[C:23]1([C:29](Cl)([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N1C=CC=CC=1>[C:23]1([C:29]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[N:3]2[C:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)=[N:6][N:5]=[N:4]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

4

반응물 2

HCID 6456Trityl chlorideHCID 14425662HCID 14425662, 화합물

생성물 1

HCID 101520195-(4'-Methyl-(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of N-trimethylstannyl 5 (4'-methylbiphenyl-2-yl)tetrazole (Example 10, 0.4 g) and anhydrous pyridine (10 mL) was treated with triphenylmethyl chloride (0.3 g) and stirred at room temperature under a nitrogen atmosphere for 48 hours. The resulting solution was evaporated and the residue was partitioned between dichloromethane and saturated aqueous CuSO4. The organic layer was dried over MgSO4 and evaporated. The residual solid was triturated with diisopropyl ether and collected by filtration to give the title compound, mp 163°-165° C. (decomp., gas evol.).

후처리

  1. customThe resulting solution was evaporated
  2. customthe residue was partitioned between dichloromethane and saturated aqueous CuSO4
  3. dry with materialThe organic layer was dried over MgSO4
  4. customevaporated
  5. customThe residual solid was triturated with diisopropyl ether
  6. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-42f3755d37e447c3bfeee3bf5b4c5f88
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05210211

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