3-Pyridin-4-YL-acrylic acid methyl ester → Methyl 3-(4-pyridyl)propanoate
반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[CH:8][C:9]([O:11][CH3:12])=[O:10])=[CH:3][CH:2]=1>[Pd].CO>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:3][CH:2]=1참가 물질
4
실험 절차
Methyl 3-(4-pyridinyl)propenoate (7.00 grams) and 10% palladium on carbon (1.00 gram) were vigorously stirred in methanol (70 mL) at room temperature under a hydrogen atmosphere for 5 hours. The catalyst was removed by filtration through a filter aide, and the filtrate was evaporated in vacuo. The crude product was purified by distillation in a kugelrohr apparatus. Yield: 5.14 grams (73%). Bp: 125° C. (oven temperature) at 0.6 mm Hg.
후처리
- customThe catalyst was removed by filtration through a filter aide
- customthe filtrate was evaporated in vacuo
- distillationThe crude product was purified by distillation in a kugelrohr apparatus
출처 및 근거
- ORD 기록
- ord-b069747be25c4f4e8fd7969622b7dc70
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05212169
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