N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide → [1-(Naphth-2-ylmethyl)piperid-4-yl]urea

HRID 248901

반응식

HRID 248901 반응식
C([NH:9][C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=2)[CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1>[OH-].[Na+]>[CH:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:28]=[CH:29][C:20]=1[CH2:19][N:16]1[CH2:17][CH2:18][CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15]1

참가 물질

3

반응물 1

HCID 72002N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide

생성물 1

HCID 13145794[1-(Naphth-2-ylmethyl)piperid-4-yl]urea

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (prepared according to Example 1) is hydrolysed by refluxing in 2N sodium hydroxide to give [1-(naphth-2-ylmethyl)piperid-4-yl]urea(m.p. 183°-5° C.). The product is acylated by reaction with 4-methoxybenzoyl chloride to give the title compound, m.p. of HCl, quarterhydrate=193°-193.5° C.).

출처 및 근거

ORD 기록
ord-471cc0bfbc9b40e7b7522546f7f5128a
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212179

연결된 노트

불러오는 중…