Water → 4-Amino-pyrido[2,3-e]pyrimidin-2-one

HRID 249078

반응식

HRID 249078 반응식
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][C:11](N)=[O:12].O>C(OCCOCCO)C>[NH2:9][C:8]1[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:11](=[O:12])[N:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 1176UreaHCID 5770153-Aminopyridine-2-carbonitrile

생성물 1

HCID 193668794-Amino-pyrido[2,3-e]pyrimidin-2-one

시약·촉매·용매 1

HCID 8146Diethylene Glycol Monoethyl Ether용매

반응 조건

온도
205 °C

실험 절차

A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.

후처리

  1. temperatureHeating
  2. filtrationfiltered
  3. customto collect the precipitate
  4. washThe precipitate was washed with water and ethyl acetate
  5. customto dry

출처 및 근거

ORD 기록
ord-8c8abec0a7934af8a15f606f2ba90a6a
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212310

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